Erythromycin genetic factors

In some strains of yeast, mutation to chloramphenicol and tetracycline resistance are associated with a decreased permealnlity of the cell-memln ane, while in the same strains mutation to macrolide (oythromydn) resistance is expressed as a change in the sensitivity of the mitochondrial protein-synthesizing system itself. For the same cell, erythromycin resistance was also shown to be extrachromosomi-cally inherited, and the corresponding genetic factor related to the mitochondrial Rho factor. The synthesis of yeast mitochondrial ribosomes seons to be (at least partly) under the control of the mitochondrial goietic determinant MDNA. 

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