Erythromycin Beckmann reaction

Benzoxazoles have been prepared by intramolecular reaction of a phenolic —OH groiq) with a Beckmann intermediate (equation 30). A cyclic imidate was isolated in high yield from tosylation and in situ Beckmann reaction of the erythromycin-derived oxime (4[Pg.698]

The reaction of 8-hydroxy acids with p-bromobenzenesulfonyl chloride in the presence of a tertiary amine gives /3-lactones (eq 5). Brosylate esters of oximes have been manipulated in the Beckmann rearrangement of erythromycin derivatives as an alternative to both 4-methylbenzenesulfonate esters and benzene-sulfonate esters. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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