ERK2 extracellular signal-regulated

ERK2 extracellular signal-regulated kinase 2 GKAP guanylate kinase-associated protein... 

DM3a - DNA methyltransferase 3A DM3b - DNA protein ERK2 - extracellular signal-regulated kinase... 

Phosphoiylation and activation of extracellular signal-regulated MAP kinases (ERKl and ERK2) were observed inMCF-7 breast cancer cells after 15 minutes of exposure to MTX (0.5 nM). Longer... 

Dziarski, R., Jin, Y.P., Gupta, D. (1996). Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. J. Infect. Dis. 174 777-85. 

Ceramide analogs that inhibit protein kinase C isoforms and induce downstream loss of extracellular signal-regulated kinase (ERK1/ERK2)... 

In preliminary experiments on the effect of yessotoxin on extracellular signal-regulated kinase (ERK), no increase in the levels of either total or phosphorylated ERKl and ERK2 isoforms in cultured cells were recorded at nanomolar concentrations of the test compound [63],... 

The activation of spinal extracellular signaling-regulated kinase-1 and -2 (ERKl, ERK2) is also required for secondary hyperalgesia [8]. Noxious activation of ionotropic, metabotropic, and tyrosine kinase receptors in dorsal horn neurons activates protein kinase A (PKA) and protein kinase C (PKC), leading to the production of ERK. Hyperalgesia after thermal stimulation is mediated by non-NMDA receptors. The thermal stimulus model demonstrates distinct protein kinase involvement downstream from spinal non-NMDA receptor activation. Jones et al. [9]... 

Fig. 10.2. Components and activation of the ERK pathway. Ordering and specificity of protein kinases in the ERK pathway. ExtraceUular signals are registered via receptor tyrosine kinases and passed on to the Ras protein. Ras GTP activates protein kinases belonging to the group of MAPKK kinases (Raf kinases and MEEKs). The MAPKK kinases phosphorylate the downstream group of protein kinases, the MAPKKs at two Ser residues. The MAPKKs phosphorylate the MAPKs (ERKl and ERK2) at a Tyr and a Thr residue, and thus are classified as dual specificity kinases. MAPK mitogenic activated protein kinase ERK extracellularly regulated kinase MEK MAP/ERK kinase MAPKK MAPK kinase MAPKKK MAPKK kinase MEKK MEK kinase.

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