Ergot alkaloids dihydro-derivatives

Stoll, Hofmann and Petrzilka (1946) have also succeeded in obtaining dihydro-derivatives of this series (ergotinine type) of ergot alkaloids. Each of these bases yields two dihydro-derivatives, distinguished as isomerides I and II. Their chief characteristics are siunmarised in the following table —... 

Ergot alkaloids, 517 characteristics, 519 constitution, 525 dihydro-derivatives, 532 hydrolytic products, 526 pharmacological action, 533 relative sympathicolytic activities, 535... 

Table 2. Physico-chemical properties of 2-(2, 3 -dihydro-3 -oxo-r,2 -benzisothiazolyl-r,r dioxide) derivatives of ergot alkaloids U... 

Ergocristine was isolated from Iberian ergot by Stoll and Burckhardt (99) in 1937 and later found by Stoll and Hofmann (10) to be a constituent of the alkaloid mixture known as ergotoxine (7). As a result of the strong sympathicolytic action of its dihydro derivative, it has found clinical application, e.g., as a component of Hydergin. 

Ergocryptine was discovered by Stoll and Hofmann as a component of the ergotoxine complex (10). It is the main alkaloid in ergot of Japanese (100) and South American (101) wild grasses. Its dihydro derivative is used as a constituent of Hydergin. 

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