Erectile dysfunction physiological

Saenz de Tejada 1, Moreland RB. Physiology of erection, pathophysiology of impotence and implications of PGEl in the control of collagen synthesis in the corpus cavernosum. In Goldstein I, Lue TF, eds. The Role of Alprostadil in the Diagnosis and Treatment of Erectile Dysfunction. Princeton, Excerpta Medica, 1993 3-16. 

As additional information about the physiological role of NO is accumulated, new ideas and strategies for the use of NO donors are emerging. For example, several studies have demonstrated the importance of NO in penile erection (Rajfer et al., 1992 Burnett et al., 1992), and it is possible that selective delivery of NO, through the use of NO donors, may improve erectile function in impotent men. Stief etal. (1992) have shown that intracavernosal injections of 0.1-1 mg of linsidomine in patients with erectile dysfunction produced dose-dependent erectile responses with no systemic or local side effects. Porst (1993) has also shown linsidomine injection to be useful in producing penile erection, but not as effective as injected prostaglandin Ei. Further studies to optimize NO delivery for erectile responses appear to be warranted. 

Intrauterine insemination (lUI) involves induction of ovulation, followed by transfer of motile sperm directly into the uterine cavity. This type of procedure is indicated if erectile dysfunction or male infertility (low motility, count, and/or poor morphology) has been identified, if the cervical environment is not conducive for effective sperm motility and/or sustenance, and if there are any physiological dysfunctions (93). 

Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction... 

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