Erectile dysfunction intraurethral alprostadil

Absorption - For treatment of erectile dysfunction, alprostadil is administered by injection into the corpora cavernosa or inserted intraurethrally. 

Alprostadil Caveqect Muse Pharmacia Upjohn AstraZeneca PGE, Ductus arteriosus 50-100 ngkg min Erectile dysfunction 5-20 fxg intracavemosally Erectile dysfunction 125-1000 fig intraurethrally... 

Intraurethral alprostadil inserts are marketed as MUSE, which contains a pellet inside a prefllled urethral applicator. Multiple studies show this product to have an overall effectiveness rate of 43% to 60%, " as compared with 70% to 90% for intracavernosal alprostadil. Its decreased effectiveness and inconvenient administration method have resulted in this product being considered a second-line treatment option for patients with erectile dysfunction. However, some patients respond to intraurethral alprostadil even when intracavernosal alprostadil did not work for them. ... 

FIGURE 81-8. Technique for administration of intraurethral alprostadil with a MUSE appi icator. Reprinted with permission from Kirby R, Carson C, Goldstein I. Erectile Dysfunction, A Clinical Guide. Oxford, England, ISIS Medical Media, 1999 62.)... 

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