Erectile dysfunction antagonists

The answer is c. (Hardmanr pp 706-708.) Spironolactone is an aldosterone antagonist that acts on the mineralocorticoid receptor It is a Kksparing diuretic. It can also function as an androgen antagonist, which could explain the gynecomastia and erectile dysfunction. Women with hirsutism are sometimes treated with spironolactone. 

Yohimbine (4.43) is an antagonist. Yohimbine, an indole alkaloid closely related to reserpine—an a antagonist—has been evaluated as a potential treatment for male erectile dysfunction. Naphazoline (4.46) and other a-agonist imidazoline compounds are nasal decongestants, used by inhalation to decrease swelling of the nasal mucosa. Overdependence on and overuse of these drugs can lead to rebound swelling. 

Alpha2 antagonists have relatively little clinical usefulness. They have limited benefit in male erectile dysfunction. There has... 

Aromatic sextets are not essential for the stability of heterocyclic rings and saturated and partially-saturated rings occur widely. These are usually named as the corresponding dihydro or tetrahydro derivatives, e.g., 37-39. The fully-saturated derivatives of pyridine and pyrazine are commonly referred to as piperidine 40 and piperazine 41. The antihypertensive calcium channel antagonist nifedipine 42 is a 1,4-dihydropyridine derivative , and sildenafil 43, which contains a piperazine ring, is a phosphodiesterase inhibitor used to treat erectile dysfunction . 

Moxisylyte is an alpha-adrenoceptor antagonist with vasodilatory activity (1). It is used orally in the treatment of peripheral vascular disease and by intracavernosal injection in erectile dysfunction. 

Erectile dysfunction a2-Antagonists Relax penile smooth muscle (central effect ) Y ohimbine... 

Other intracorporal agents used to induce penile erections include papaverine, a drug with a relaxant effect on smooth muscle, and phentolamine, an a-adrenergic receptor blocker. Yohimbine, an a2-adrenoreceptor antagonist, enhances noradrenergic neurotransmission and may improve erectile dysfunction via adrenergic system activation. 

The final three indole-containing drugs approved for animals in the U.S. are indole alkaloids. Metoserpate 6 is a water-soluble reserpine alkaloid given to reduce stress and prevent hysteria in poultry. Yohimbine 7 is a central alpha-2 adrenergic antagonist. It is used in dogs to reverse the anesthesia produced by the commonly used anesthetic Xylazine. Strychnine 8 is a rodenticide (Scheme 10). There is no current approved human medical use for metoserpate although yohimbine is prescribed for erectile dysfunction. Strychnine, once used in small doses as a laxative... 

The hypotensive adverse effects of apomorphine may possibly be increased by alcohol. The concurrent use of other drugs used for erectile dysfunction or dopamine agonists or antagonists is not recommended. However, domperidone, and prochlorperazine are said not to interact when apomorphine is used for erectile dysfunction, and domperidone is the recommended antiemetic when apomorphine is used for Parkinson s disease. There is evidence that antidepressants, antiepileptics, and ondansetron do not interact adversely. 

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