Equanil - Meprobamate

Synonyms Miltown Equanil Meprobam Meprobamatum Procalmadiol 2,2-Di(carbamoy-loxymethyl)pentane Carbamic acid 2-methyl-... 

Meprobamate Equanil, Miltown, Meprotabs 400 delirium upon sudden withdrawal 1.6-3.2 g x 270 days 8-12 3-8... 

I particularly recalled my clinical work in 1958 and early 1959, when my assignment was to care for hospitalized soldiers and their dependents. We had few drugs to work with in those days. We relied mainly on Thorazine in the treatment of psychotic patients. It was the first major tranquilizer and preceded by decades the wonder drugs used today. For less severely disturbed patients we used meprobamate (Equanil) which has all but disappeared from today s pharmacies. In fact, the value of lithium, for mood swings, was just beginning to be accepted. 

Nonbarbiturates. After the introduction of the barbiturates, there was little progress in the medical treatment of anxiety until meprobamate (Equanil, Miltown) was introduced in 1950. Soon after its introduction, a series of similar medicines entered the market, including carisoprodol (Soma), glutethimide (Doriden), methaqualone (Qaalude, Sopor), methyprylon (Noludar), and ethchlorvynol (Placidyl). These medications have all been used to treat anxiety, insomnia, and muscle spasms. 

Some tranquilizers namely, chlordiazepoxlde and meprobamate, are relatively mild tranquilizers suitable for relieving tension. Equanil is used in controlling depression and hypertension. 

Meprobamate was proposed before the introduction of benzodiazepines into medical practice. The exact mechanism of action of this drug is not known however, its effects on the CNS are more similar to the effects barbiturates than to benzodiazepines, but with shorter-lasting action. After the introduction of benzodiazepines into practice, the use of this drug became significantly less. Meprobamate is used primarily as a daytime anxiolytic in treating conditions of anxiety associated with everyday, usual, and common stress. Synonyms for this drug are cypron, equanil, stenzol, mepron, miltaun, and others. 

Meprobamate (Miltown and Equanil) This is a highly addictive and sedating anxiolytic. Those using meprobamate for prolonged periods may become addicted and may need to be withdrawn slowly. High... 

Meprobamate (Miltown, Equanil) was introduced in the 1950s. It had the effect of relieving anxiety without producing sleep. However, regular use produced psychological and physical dependence. 

The drugs in Schedule IV have a relatively low abuse potential and risk for psychological or physical dependence relative to those listed in Schedule in and include such drugs as barbital, phenobarbital, methylphe-nobarbital, chloral betaine (Beta Chlor), chloral hydrate, ethchlorvynol (Placidyl), ethinamate (Valmid), meprobamate (Equanil, Miltown), paraldehyde, methohexital, fenfluramine, diethyipropion, phentermine, chlor-diazepoxide (Librium), diazepam (Valium), oxazepam (Serax), clorazepate (Tranxene), flurazepam (Dalmane), clonazepam (Clonopin), prazepam (Verstran), lorazepam (Ativan), mebutamate, and dextropropoxyphene (Dar-von). 

Parenteral 25, 50 mg/mL for injection Meprobamate (generic, Equanil, Miltown) Oral 200, 400 mg tablets Oral sustained-release 200, 400 mg capsules Paraldehyde (generic)... 

Equanil. [Wyeth-Ayerst] Proprietary name for meprobamate. 

Mendocino Indians ofNorth America—407 Menominee Indians of N. America-108,406 Meperidine (pethidine, Demerol )- ), ) ) meprobamate Equanil )-1%... 

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