EPSP synthetase

Arom 1 4 DHS reductos Arom 9 3 0 hydfD- quinase Arom 5 5 SA kinase Arom 4 6 EPSP synthetase Arom 2 2 DHQ Synthetase... 

A highly specialized synthesis converted (-)-shikimic acid 7.169) to 7.170. Reaction with azide and catalytic hydrogenation gave 5-aminoshikimate 7.171, methyl 5-amino-3,4-dihydroxy-l-cyclohexene carboxylate) in 21% overall yield. Amino acid 7.171 is an inhibitor of EPSP synthetase, and can be used as an herbicide,... 

Examples EPSP Synthase, Myosin, Tyrosyl-tRNA Synthetase, and DNA Polymerase... 

C3b2. Inhibition of acetolactate and acetohydroxyacid synthases (B) C3b3. Inhibition of EPSP synthase (G) C3b4. Inhibition of glutamine synthetase (H)... 

Of the enzymes associated with aromatic amino acid biosynthesis, there is good evidence that unique isozymes of DAHP (Rubin and Jensen, 1985), chorismate synthetase (d Amato et al 1984), and anthranilate synthase (Brotherton et ai, 1986) are differentially localized within chloroplasts and in the cytoplasm. The regulatory properties of the plastid isozymes are consistent with their involvement in amino acid synthesis. Many of the remaining pathway enzymes have also been detected in plastids, including all those required for the synthesis of EPSP [(1) to (6)] (Mousdale and Coggins, 1985). These results, combined with those obtained during measurements of the biosynthetic capabilities of isolated chloroplasts (Bickel and Schultz, 1979 Buchholz and Schultz, 1980 Schulze-Siebert et ai, 1984), leave little doubt that these organelles are a primary site of aromatic amino acid biosynthesis. 

---