Epoxide hydrolases -epichlorohydrin

Rossi, A.M., Migliore, L., Loprieno, N., Romano, M. Salmona, M. (1983b) Evaluation of epichlorohydrin (ECH) genotoxicity. Microsomal epoxide hydrolase-dependent deactivation of ECH mutagenicity in Schizosaccharomyces pombe in vitro. Mutat. Res., 109. 41-52... 

First hints on the stereoselectivity of halohydrin dehalogenases were obtained from studies on the desymmetrization of prochiral 1,3-dichloropropan-2-ol yielding epichlorohydrin using resting cells of Corynebacterium sp. (Scheme 2.235) [1836]. In two-step sequence, (/ )-3-chloropropane-l,2-diol was formed in 74% e.e. via epichlorohydrin through the sequential action of an (unspecified) halohydrin de-halogenase and an epoxide hydrolase [1837]. Further studies revealed that these activities are widespread among bacteria [1838-1842]. 

Yildirim, D., Tiikel, S.S., Alptekin, O. and Alagoz, D. (2013) Immobilized Aspergillus niger epoxide hydrolases cost-effective biocatalysts for the preparation of enantiopure styrene oxide, propylene oxide and epichlorohydrin. /. Mol. Catal. B Enzym., 88, 84r-90. 

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