Epoxidation and Aromatic Hydroxylation

1a Epoxidation and Aromatic Hydroxylation. Epoxidation is an extremely important microsomal reaction because not only can stable epoxides be formed but arene oxides, the epoxides of aromatic rings, are intermediates in aromatic hydrox-ylations. In the case of polycyclic hydrocarbons, the reactive arene oxides are known to be involved in carcinogenesis. 

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Haloperoxidases are peroxidases capable of halogenating substrates in the presence of halide and hydrogen peroxide [14] or other reactions such as sulfoxidation, epoxidation and aromatic hydroxylation. Here, the halide ion is initially bound to the active site which may incorporate heme or vanadium or be metal free. The halide ion is incorporated into the substrate after electron transfer... 

Figure 10.1. Examples of epoxidation and aromatic hydroxylation reactions.

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