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Epilepsy cellular mechanisms

Cellular mechanisms underlying hyperexcitability have been analyzed by electrophysiological studies of hippocampal slices isolated from animals with epilepsy 632... [Pg.629]

Delorenzo, RJ, Sun, DA, Deshpande, LS (2005) Cellular mechanisms underlying acquired epilepsy the calcium hypothesis of the induction and maintainance of epilepsy. Pharmacol Ther, 105 229-266. [Pg.106]

The epilepsies constitute a common, serious neurological disorder in humans, affecting approximately 60 million people worldwide. Well in excess of 40 distinct epileptic syndromes have been identified to date. Current treatment is only symptomatic except in uncommon instances when surgical treatment is possible. While available antiseizure medications target ion channels such as the y-amino-butyric acid (GABA)a receptor and voltage activated sodium (Na+) channels, current research seeks to elucidate the cellular and molecular mechanisms by which a normal brain becomes epileptic. Hopefully, this research will lead to the identification of new targets for which small molecules can be identified and used for prevention or cure of epilepsy. [Pg.629]

While there seems to be little in common between intractable epilepsy and cancer, researchers in each field have focused on a common mechanism underlying multidrug resistance a cellular pump called P-glycoprotein (Pgp). Pgp protects cells from toxic substances by actively excreting the toxic agent. The pumps reside in tissues that are extensively exposed to toxic material liver, lungs, kidney, intestine, placenta, and blood-brain barrier. How-... [Pg.390]


See other pages where Epilepsy cellular mechanisms is mentioned: [Pg.633]    [Pg.533]    [Pg.109]    [Pg.128]    [Pg.631]    [Pg.100]    [Pg.128]    [Pg.242]    [Pg.109]    [Pg.109]    [Pg.322]    [Pg.456]    [Pg.449]    [Pg.511]    [Pg.491]   
See also in sourсe #XX -- [ Pg.632 ]




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