Epigastric pain vitamin

A 37-year-old HIV-infected woman receiving stavudine, lamivudine, and indinavir developed epigastric pain, anorexia, and vomiting. She had lactic acidosis (serum lactate 4.9 mmol/1), raised liver enzymes, and an increased prothrombin time. She had hepatomegaly and tachypnea and required mechanical ventilation. Her progress was complicated by pancreatitis and acute respiratory distress syndrome. Antiviral medication was stopped and she was treated with co-enzyme Q, carnitine, and vitamin C. The serum lactic acid and transaminases returned to normal over 4 weeks and she was weaned off the ventilator after 4 months. 

The relationship between vitamins C and E supplementation and the markers of haemolysis in sickle cell anaemia has been evaluated in a six-month randomised, double-blind, placebo-controlled trial including 83 patients [29 ]. The most commonly reported adverse events in the vitamins versus placebo group were headache (18% vs 10%), nausea (14% vs 10%), fatigue (11% vs 13%), diarrhoea (7% vs 0%), and epigastric pain (5% vs 1%). All serious adverse events were sickle cell anaemia-related. 

Observational studies The effect of daily therapy with lyg alfacalcidol for 6 months on musculoskeletal function in elderly patients with reduced bone mass has been examined. Adverse effects reported included epigastric pain, nausea, vomiting, agitation, chest pain, asthenia, dehydration, malaise, muscle spasm, pruritus and gastroenteritis. No serious adverse reactions or hypercalcaemia was observed [35 -]. No adverse events were associated with vitamin... 

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See also in sourсe #XX -- [ ]

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