Epidermodysplasia verruciformis

In condylomata acuminata, gross and microscopic fluorescence spectra suggested selectivity (68%) of PpIX formation after topical ALA application [115]. The greatest lesional to normal skin fluorescence ratios occurred after 2 h. A patient with epidermodysplasia verruciformis (types of human papilloma virus were proven in lesional skin) presenting wart-like lesions on the hands, lower arms and forehead was treated using 20% ALA for 6 h and incoherent light 580-740 nm, 160 mW cm", 160 J cm", with an excellent cosmetic result [116]. In situ hybridization was positive for HPV type 8 in skin which was clinically and histologically normal. Twelve months after PDT a few lesions had recurred on the hands. 

S. Karrer, R.M. Szeimies, C. Abels, U. Wlotzke, W. Stolz, M. Landthaler (1999). Epidermodysplasia verruciformis treated using topical 5-aminolaevulinic acid photodynamic therapy. Br. J. Dermatol, 140, 935-938. 

Jablonska S, Majewski S 1994 Epidermodysplasia verruciformis immunological and clinical aspects. Curr Top Microbiol Immunol 186 157-175... 

Kurima K, Yang Y, Sorber K, Griffith AJ 2003 Characterization of the transmembrane channellike (TMC) gene family functional clues from hearing loss and epidermodysplasia verruciformis. Genomics 82 300-308... 

Etretinate has also been found to be effective in the treatment of epidermodysplasia verruciformis induced by the oncogenic human papilloma virus (HPV) type 5 and the nononcogenic type 3. However, in one patient, the wart virus could still be detected during therapy. Relapse followed a decrease in dosage (Lutzner et al., 1981). 

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