Epidermis cell kinetics

Van Scott and Ekel in 1963 (V4) studied epidermal cell kinetics by projecting histologic sections of lesions. They traced the architecture of the epidermis, counted the number of mitoses present, and determined the relationship of the proliferative cell population to the skin surface, to the viable epidermal cell population, and to the epidermis as a whole. This was repeated in from 6 to 24 sequential 8-/t-thick sections, and a... 

Fig. 12. The kinetics of contraction of full-thickness guinea pig skin wounds separate collagen-GAG matrices into three classes. The wound half-life t,/2 is the number of days necessary to reduce the original wound area to 50%. An inactive matrix does not delay wound contraction significantly relative to the ungrafted control and eventually allows formation of a linear scar. An active, cell-free matrix delays wound contraction by about 20 days but eventually allows lull contraction to occur. An active matrix, which has been seeded with a minimal number of skin cells, delays contraction significantly, later arrests it, and eventually induces synthesis of a new dermis and epidermis within an expanding wound perimeter...

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