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Epidermal growth factor decreased dependence

Exposure of PC12 cells to 500 pM peroxynitrite activated extracellular-regulated kinases 1 and 2 and p38 within 5 min and this was followed by gradual decreases in activation over the next 25 min (JoPE etal. 2000). Activation of extracellular-regulated kinases 1 and 2 by peroxynitrite was mediated by activation of the epidermal growth factor receptor in a calcium/calmodulin-dependent kinase II- and sre family tyrosine kinase-dependent manner, as it was blocked by the selective epidermal growth factor receptor inhibitor AG1478, by... [Pg.519]

See other pages where Epidermal growth factor decreased dependence is mentioned: [Pg.221]    [Pg.486]    [Pg.531]    [Pg.107]    [Pg.356]    [Pg.28]    [Pg.65]    [Pg.387]    [Pg.170]    [Pg.87]    [Pg.88]    [Pg.186]    [Pg.140]    [Pg.65]    [Pg.173]    [Pg.22]    [Pg.87]    [Pg.289]    [Pg.264]    [Pg.624]    [Pg.101]    [Pg.236]    [Pg.35]    [Pg.435]   


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Decrease

Decreasing

Epidermal

Epidermal growth factor

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