Epichlorohydrin from allyl alcohol

AMINOPENTANE (110-58-7) Forms explosive mixture with air (flash point 30°F7 -1°C also reported at 45°F/7°C oc). A weak base. Keep away from heat, sunlight. Incompatible with strong oxidizers, acids, organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. May accumulate static electrical charges, and may cause ignition of its vapors. 

Uses From 3-chloropropene mainly epichlorohydrin (90 % of the use), glycerol, and allyl alcohol are prepared. The world production in 1997 was 800 0001 allyl chloride. 

SODIUM BICARBONATE (497-19-8) CHNaOj Noncombustible solid. Aqueous solution is a strong base. Violent reaction with acids evolving carbon dioxide. Violent reaction with finely divided aluminum, fluorine, lithium. Incompatible with organic anhydrides, acrylates, alcohols, aldehydes, alkylene oxides, substituted allyls, cellulose nitrate, cresols, caprolactam solution, epichlorohydrin, ethylene dichloride, isocyanates, ketones, glycols, nitrates, phenols, phosphorus pentoxide, 2,4,6-trinitrotoluene. Forms explosive material with 2,4,5-trinitrotoluene and increases the thermal sensitivity of 2,4,6-trinitrotoluene (TNT) by decreasing the tenqjerature of explosion from 566°F/297°C to 424°F/218°C. Attacks metals. Thermal decomposition at 228°F/109°C, releasing oxides of carbon. 

Non-racemic epoxide 307, prepared from (+)-epichlorohydrin, was alkeny-lated to give allyl silane 308, which was converted into allyl stannane 309. Corey s chiral boron reagent-mediated asymmetric allylation [120] to aldehyde 311 provided homoallylic alcohol 306 with a 11 1 diastereomer ratio. Intramolecular Sn2 cyclization of the corresponding 7-hydroxy-3-TsO unit derived from 306, followed by hydrolysis of the dithiane, afforded aldehyde 312 (Scheme 66). 

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