Ephedrine-imprinted polymers

Other SPME-IMS methods that have been reported for application to pharmaceutical or related samples include those for analysis of ephedrine in urine, meth-amphetamines in human serum, and captopril in human plasma and pharmaceutical preparations. In a method similar to SPME-IMS, testosterone was collected with a molecular imprinted polymer from urine and desorbed into an IMS. The method was validated with HPLC and determined to have a detection limit of 0.9 ng/mL with a linear dynamic range from 10 to 250 ng/mL. ... 

Legge, C., and Turner, A. P. F. (2001). Recognition of ephedrine enantiomers by molecularly imprinted polymers designed using a computational approach, 126,1826-1830. 

An (-)-Ephedrine voltammetric sensor prepared through the immobilization of an MIP imprinted polymer for ephedrine in the range of 0.5-3 mM [426], and the MIP-coated gold electrode modified by chitosan-platinum nanoparticles (CS-PtNPs) and graphene-gold nanoparticles (GR-AuNPs) nanocomposites for the determination of erythromycin are other examples of the application of MIPs for the analysis of pharmaceutical species. The latter report used erythromycin as template and 2-mercapto-nicotinic acid functional monomers and yielded a linear response in the range of 7.0 x 10 -9.0 X 10 M and a detection limit of 2.3 x 10 M [378]. 

Ansell, R.J. and Kuah, K.L., Imprinted polymers for chiral resolution of ( )-ephedrine understanding the pre-polymerization equilibrium and the action of different mobile phase modifiers, A a/yif, 130, 179-187, 2005. 

Preparation of Synthetic Polymers Imprinted with (H-)-Ephedrine, (H-)-Pseudoephedrine, and (H-)-Norephedrine [48]... 

Successively, Suedee et al. [48] used MIP plates prepared by thermal polymerization methods and imprinted with (+)-ephedrine, (+)-pseudoephedrine, and (+)-norephedrine for the separation of a-agonists, -agonists, and -antagonists using mixtures of 5 or 10% acetic acid in methanol or dichloromethane as mobile phases in planar chromatography. Propanolol, pindolol, and oxprenolol were baseline separated by all the polymers imprinted with the aforementioned a-agonists with a-values ranging from 1.43 to 2.16. 

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