Ephedrine cardiovascular diseases

Many United States consumers have embraced the use of botanicals and other supplements as a "natural" approach to their health care. Unfortunately, misconceptions regarding safety and efficacy of the agents are common, and the fact that a substance can be called "natural" of course does not guarantee its safety. In fact, these products can be adulterated, misbranded, or contaminated either intentionally or unintentionally in a variety of ways. Furthermore, the doses recommended for active botanical substances may be much higher than those considered clinically safe. For example, the doses recommended for several Ma-huang preparations contain three to five times the medically recommended daily dose of the active ingredient, ephedrine—doses that impose significant risks for patients with cardiovascular disease. 

Owing to its sympathomimetic activity, ephedrine may be contraindicated for individuals with hypertension or other cardiovascular diseases, glaucoma, diabetes, and hyperthyroidism [64]. 

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