Temperature and enzymes

Further, the change in the tumor microenvironment such as pH, enzyme, temperature, and redox potential can be used to further control the drug release at the target site... 

Endo-acting a-amylases that produce large quantities of maltohexaose from starch are secreted by various bacilli. Bacillus circulans strains G-6 (41) and F-2 (42) were discovered independently and shown to produce such enzymes. Temperature and pH optima vary considerably between these enzymes, strain F-2 producing the more temperature stable (opt. SO C) amylase with a lower pH optimum for activity (6-6.5). This enzyme also has considerable activity on raw starch (43). 

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