Enzymes strategies

Venkatakrishnan, K., Obach, R.S. and Rostami-Hodjegan, A. (2007) Mechanism-based inactivation of human cytochrome P450 enzymes strategies for diagnosis and drug—drug interaction risk assessment. Xenobiotica, 37, 1225—1256. 

Bemkop-Schnilrch A, Giovanelli R, Valenta C Peroral administration of enzymes Strategies to improve the galenic of dosage forms for trypsin and bromelain, Dev Ind Pharm 2000, 26, 115-121. 

Femandez-Lafuente, R., 2009. Stabihzation of multimeric enzymes strategies to prevent subunit dissociation. Enzyme Microb. Technol. 45 (6—7), 405—418. 

It was shown that the incorporation of monooxygenases into cascade networks allows the efficient interconversion of diverse functional groups. DiHerent approaches have proved to be suitable for multistep bio transformations, ranging from fusion enzyme strategies for facile cofactor recycHng to artificial metal-loenzymes. However, monooxygenases seem to perform preferably well within a... 

Krauss, U., Drepper, T., Jaeger, K. E. (2011). Enlightened enzymes strategies to create novel photoresponsive proteins. Chemistry — A European Journal, 17, 2552-2560. http //dx.doi.Org/10.1002/chem.201002716. 

The years that have passed since Sanger determined the structure of insulin have seen refinements m technique while retaining the same overall strategy Enzyme cat alyzed hydrolysis to convert a large peptide to smaller fragments remains an important... 

Several strategies for the production of pure D- or L-amino acids rely on the use of enzymes. L-Serine (49) is synthesized by combining glycine (48) and formaldehyde in the presence of the enzyme serine hydroxymethyl transferase (66). 

Enzymes Degrading Macromolecules. Enzymes that degrade macromolecules such as membrane polysaccharides, stmctural and functional proteins, or nucleic acids, have all shown oncolytic activity. Treatment strategies include the treatment of inoperable tumors with pepsin (1) antitumor activity of carboxypeptidase (44) cytotoxicity of ribonudease (45—47) oncolytic activity of neuraminidase (48—52) therapy with neuraminidase of patients with acute myeloid leukemia (53) antitumor activity of proteases (54) and hyaluronidase treatment in the management of human soHd tumors (55). 

There are two basic strategies for enzyme-catalyzed peptide synthesis equiUbrium- and kineticaHy controlled synthesis. The former is the direct reversal of proteolysis and involves the condensation of an amino component with unactivated carboxyl component. The latter proceeds by the aminolysis of an activated peptide ester. 

A NOVEL STRATEGY FOR THE DEVELOPMENT OF BIOSENSORS BASED ON NAD-DEPENDENT ENZYMES... 

Several approaches to enantioselective synthesis have been taken, but the most efficient are those that use chiral catalysts to temporarily hold a substrate molecule in an unsymmetrical environment—exactly the same strategy that nature uses when catalyzing reactions with chiral enzymes. While in that unsymmetrical environment, the substrate may be more open to reaction on one side than on another, leading to an excess of one enantiomeric product over another. As an analog)7, think about picking up a coffee mug in your... 

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