Enzymes Adenosinetriphosphatase

Derivation (1) From adenosine triphosphate by hydrolysis with the enzyme adenosinetriphosphatase from lobster or rabbit muscle (2) by yeast phosphorylation of adenosine. 

C10H15N5O10P2 427.203 Formed from ATP in the muscle by the enzyme adenosinetriphosphatase. Prod, by various bacteria. Platelet aggregating factor. Inhibits adenylate cyclase. P2 receptor agonist. 4 pAa, 6.48 (25°, Q.15M NaCl). Kax 259 (e 15400) (H2O). 

M. Caffrey and G. W. Feigenson, Fluorescence quenching in model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics, Biochemistry 20, 1949-1961 (1981). 

Biain adenosinetriphosphatase This enzymatic activity is persistendy associated with brain micFotubules even after multiple cycles of warm-induced microtubule assembly, centrifugation to separate protomer and polymer, cold-induced disassembly, and subsequent centrifugation to remove cold-stable aggregates (White et aL, 1980). The enzyme hydrolyzes boA GTP and ATP, and recent work by Tominaga and Kaziro (1982) indicates that there are two distinct ATP-ases, one that is of low M, (around 33,000) and tubulin dependent in the presence of calcium ion, and the other of larger size and associated with membrane vesicles... 

Johnson KA. Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates. Methods Enzymol. 1995 249 38-61. 

There are also several enzymes attached to the plasma membrane which control the structure and fimction of the membrane, and the activities of these enzymes may be controlled by zinc. Adenosinetriphosphatase (ATPase) and phospholipase A2 are known to be inhibited by zinc, and... 

Na+ -p K+) Adenosinetriphosphatase is the membrane-bound enzyme that transports sodium and potassium in opposite directions across the cell membrane to create the ion gradients that are utilized to perform physiological functions. The cardiac glycosides and aglycons, such as digoxin, ouabain, and strophanthidin, are natural products that have been used therapeutically for centuries in the treatment of heart disease. Their only known biochemical effect is to inhibit specifically (Na+-j-K ) adenosinetriphosphatase and consequently decrease or completely stop active cation flux. 

There are at least three enzymes which will hydrolyze adenosine triphosphate. Myosin, one of the active proteins of muscle, has very strongly associated with it an adenosinetriphosphatase which is activated by calcium ions and inhibited by magnesium. Cleavage of only the terminal phosphate of ATP occurs, and inosine triphosphate is the only other substrate attacked. Not associated with myosin is a water-soluble adenosinetriphosphatase described by Kielley and Meyerhof. It is strongly... 

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