Enzyme motion

Hydrogen motion, H+, H or H, is often involved in the rate-limiting step of many enzyme catalysed reactions. Here, QM tunnelling can be important and is reflected in the values of the measured kinetic isotope effects (KIEs) [75], Enzyme motion... 

Antoniou, D. and Schwartz, S.D. (2001) Internal enzyme motions as a source of catalytic activity rate-promoting vibrations and hydrogen tunneling, J. Chem. Phys. B 105, 5553-5558. 

Currently suggested models for tunneling increasingly invoke protein dynamics . These models envision either a series of conformational fluctuations that lead to a suitable tunneling configuration ( passive dynamics ) or a more active role for the enzyme motions ( active dynamics or gating ).64 On the model of... 

Billeter, S.R., et al. (2001). Hydride transfer in liver alcohol dehydrogenase quantum dynamics, kinetic isotope effects, and role of enzyme motion. J. Am. Chem. Soc. 123, 11262-11272... 

S. Hammes-Schiffer (2002) Impact of enzyme motion on activity. Biochemistry 41, p. 13335... 

This review is not meant to be comprehensive of all work on enzyme dynamics and catalysis. The emphasis will be on the work done by our group, mainly on fast sub-ps enzyme motions, while other groups have studied mostly conformational fluctuations. When necessary, we will provide brief descriptions and references to the current work by other groups. 

Agarwal, P. K., Iordanov, T., Hammes-Schiffer, S., Hydride Transfer in Liver Alcohol Dehydrogenase Quantum Dynamics, Kinetic Isotope Effects, and Role of Enzyme Motion, J. Am Chem. Soc. 2001, 123, 11262-11272. 

D. Antoniou, S. D. Schwartz, Internal Enzyme Motions as a Source of Catalytic Activity Rate Promoting Vibrations and Hydrogen Tunneling, J. Phys. Chem. B, 105, 5553-5558 (2001). 

Internal enzyme motions as a source of catalytic activity rate-... 

Devices like this have been used to detect binding events on CNTs and semiconductor nanowires. More recently, CNT FETs have been used to study enzyme motion at the single-molecule... 

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