Enzyme-linked caspase-7 processing

In some studies it has been shown that ITCs can cause increases in the pro-apoptotic caspase enzymes, caspase 3, caspase 8 or caspase However, in other work, specific caspase inhibitors failed to block cell death or cell detachment from the substratum . This suggests that caspase-activation may only be a bystander event, or may only occur after the initiating event of a block in the cell cycle. Indeed, although expression of c-Jun amino-terminal kinase (INK) in response to ITCs has been linked to the pro-apoptotic process, it remains entirely possible that this is a parallel signalling pathway, more closely related to the induction of Phase 1 or Phase 2 enzymes than to the... 

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery The biochemical mechanisms underlying proinflammatory cytokine maturation and cellular apoptosis are linked by the family of cysteine proteases known as caspases. These enzymes have necessary roles in both processes and are widely considered as promising targets for drug discovery. ... 

---