Enzyme kinetics Michaelis-Menton equation

Non-linear pharmacokinetics are much less common than linear kinetics. They occur when drug concentrations are sufficiently high to saturate the ability of the liver enzymes to metabolise the drug. This occurs with ethanol, therapeutic concentrations of phenytoin and salicylates, or when high doses of barbiturates are used for cerebral protection. The kinetics of conventional doses of thiopentone are linear. With non-linear pharmacokinetics, the amount of drug eliminated per unit time is constant rather than a constant fraction of the amount in the body, as is the case for the linear situation. Non-linear kinetics are also referred to as zero order or saturation kinetics. The rate of drug decline is governed by the Michaelis-Menton equation ... 

Equation 9 is a hyperbolic relationship, similar to the Michaelis-Menton equation derived for enzyme kinetics (104) the Langmuir equation as applied to adsorption on soils (105), and an adaptation of these models for dechlorination by Fe that we published previously (13). As such, all four models are capable of describing site saturation phenomena commonly found in heterogenous systems however, only the new model (equations 8 and 9) explicitly distinguishes thermodynamically-related parameters from the kinetic constants. 

Estimation of Kinetic parameters of Enzyme Catalysed Reaction S % Michaelis - Menton rate equation % Reaction rate - (-ra) = (kl Cs)/(Km+Cs)... 

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