Enzymatic substitution at phosphorus

Among the most important reactions in biochemistry are those that involve substitution at phosphorus in phosphates. These reactions are involved in energy transduction, replication, transcription and recombination of nucleic acids, metabolic regulation, and metabolic pathways including biosyntheses of nucleotides, amino acids, proteins, complex lipids and complex carbohydrates. They are among the most intensively studied proteins in biochemistry, both because of their fundamental importance and because they present special challenges as research subjects. 

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Stereochemistry of enzymatic substitution at phosphorus (c) Chiral metal-nucleotides... 

The stereochemical course of enzymatic substitution at phosphorus has been determined for over thirty enzymes. While most of these studies have been completed... 

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