ENOS cDNA

Because most solid tumors contain hypoxic areas, a certain number of solid tumors show a resistance to radiotherapy (De Bidder et al. 2008). NO from endothelial NOS (eNOS) significantly inhibited fiver metastasis and significantly prolonged survival after implantation of L3.6 pancreatic cancer cells transfected with L3.6-eNOS cDNA via portal vein injection compared with those transfected with L3.6-LacZ (control) cDNA in SCID mice (Decker et al. 2008). NO from eNOS was demonstrated to result in down-regulation of the matrix protease cathepsin B which is responsible for invasive capacity of cancer cells (Decker et al. 2008). 

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