Enhancement programs manipulation

In the study of isozyme-selective modulators for protein kinase C (PKC), docking simulations of the benzolactam 16 (BL-V8) with the crystal structure of the PKCd) C1B domain were performed using the FlexX program in SYBYL <2005JA5746>. The data provided evidence that the CH-Jt-interaction plays a pivotal role in the binding of 16 to the PKC5 C1B domain. The binding affinity was enhanced in the naphtholactam 17 (NL-V8) by the effective manipulation of the CH-7l-interaction. 

The Facility Supervisor and Hot Cell Operators are qualification positions requiring successful completion of a formal training program before an individual Is allowed to operate specific HCF equipment and/or controls unsupervised. Proficiency for the qualified positions is demonstrated by minimum acceptable scores on written tests and by observation of the individual s operating skill with manipulators, production process equipment, and plant safety equipment and safety systems. Qualification also requires demonstrated adherence to conduct of operations principles, ability to follow procedures, and commitment to cultivating an environment of teamwork and continuous improvement. Staff contributions to improvement of procedures and processes are actively encouraged as a way to enhance the safety and work culture. 

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