Energy parameter optimization, protein

When a reasonably good estimate for the entropy function of a protein model is obtained by the ESMC method, the foldability of the model can be determined therefore, in later studies [25-27], the entropy function computed by the ESMC method was used as a monitor for optimization of the interaction energy parameters for folding protein models. 

Keywords, protein folding, tertiary structure, potential energy surface, global optimization, empirical potential, residue potential, surface potential, parameter estimation, density estimation, cluster analysis, quadratic programming... 

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