Energy landscape theory

Plotkin, S.S., Onuchic, J.N. Understanding protein folding with energy landscape theory. Part I Basic concepts. Q. Rev. Biophys. 2002, 35, 111-67. 

Computer simulation using lattice models and energy landscape theory using abstract models predict that the fastest folding of small proteins should occur without intermediates and by an extended nucleation process. Stable intermediates slow... 

The current status of the problem of de novo design of proteins and prospects in the area including energy landscape theory of protein folding, atomistic and minimal... 

Massi, F. Straub, J.E. Energy landscape theory for Alzheimer s amyloid p-peptide fibril elongation. Proteins Struct. Funct. Genet. 2001, 42, 217-229. 

The lattice models mentioned above were among the first to test the predictions of energy landscape theory as well as to show that many important features in protein folding could be captured by simple physical principles. In other studies, lattice models have been extended to include side-chain elements,side-chain-only models, and diamond, body-centered cubic (bcc) and face-centered cubic (fee) lattices. These models, while maintaining their simplicity and computational tractability, are much more realistic than those discussed above, and will likely provide further insight into the interactions that drive protein folding. For an excellent review on reduced protein models, we refer the reader to Kolinski and Skolnick and the extensive references therein. ... 

The Energy Landscape Theory of Protein Folding Insights into Folding Mechanisms and Scenarios. 

F. MassiandJ. E. Straub, Proteins, 42,217 (2001). Energy Landscape Theory for Alzheimer s... 

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