Enediyne natural product biosynthesis

Shen, B., Liu, W. and Nonaka, K. (2003) Enediyne natural products biosynthesis and prospect towards engineering novel antitumor agents. Current Medicinal Chemistry, 10, 2317. 

Shen B, Liu W, Nonaka K (2003) Enediyne Natural Products Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents. Curr Med Chem 10 2317... 

Timothy J. Montavon was born in Wheelersburg, OH, in 1982. He attended Xavier s University in Cincinnati, OH, where he earned a B.S. in chemistry in 2004. While at Xavier s, he worked in the laboratory of Professor Aaron Baba developing novel fluoroiono-phores. In 2004, he began attending graduate school at Boston College working in the laboratory of Professor Steven Bruner. His current research is focused on the structure and mechanism of aminomutase enzymes used in the biosynthesis of enediyne natural products. 

Liang, Z.-X. (2010) Complexity and simplicity in the biosynthesis of enediyne natural products. Natural Product Reports, 27(4), 499-528. 

The three types of PKSs described here, the enediyne PKS, the C-0 bondforming PKS, and the AT-less PKS, are only representive examples that reside outside the archetypical PKS paradigms. Continued exploration on the mechanism of polyketide biosynthesis will undoubtly uncover more unusual PKSs. These novel PKSs, in combination with the archetypical ones, will ultimately enhance the toolbox available to facilitate combinatorial biosynthesis and production of iinnatural natural products. The full realisition of the potential embodied by combinatorial biosynthesis of PKSs for natural product structural diversity, however, depends critically on the fundamental characterization of PKS structure, mechanism, and catalysis. 

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