Endotoxin disseminated intravascular coagulation

K5. Kawamura, M Terashita, Z Imura, Y., Shino, A., and Nishikawa, K Inhibitory effect of TCV-309, a novel platelet activating factor (PAF) antagonist, on endotoxin-induced disseminated intravascular coagulation in rats Possible role of PAF in tissue factor generation. Thromb. Res. 70,281-293(1993). 

Another model that is also used widely in rats and mice is a model of systemic thrombosis or disseminated intravascular coagulation (DIC), which is induced by tissue factor, endotoxin (lipopolysaccharide), or FXa (Herbert et al. 1996 Yamazaki et al. 1994 Sato et al. 1998). After systemic administration of the thrombogenic stimulus, this model can be performed with or without mechanical vena caval stasis. When stasis is used, the major parameter is the thrombus mass, but when stasis is not used, the readouts are... 

It is known that endotoxin causes the reduction of blood platelet numbers and fibrinogen content, the increase of fibrin degradation product (FDP) and the prolongation of prothrombin time. The oral administration of baicalein (50 mg/kg) and baicalin (50 mg/kg) prevented the reduction of blood platelet number and fibrinogen content in rats with endotoxin-induced disseminated intravascular coagulation (DIC) "Table (16)". [31]... 

Table 16. Effects of baicalein and baicalin on the endotoxin-induced disseminated intravascular coagulation (DIG) in rats...

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