Endogenous Hyperglyceridemia with Essential Hypercholesterolemia

Fredrickson and Lees (1965) have described as their type III hyperlipoproteinemia, individuals who, in addition to clinical and laboratory evidence of essential hypercholesterolemia, show elevation of VLDLP (pre-j8-lipoproteins) and are markedly susceptible to carbohydrate induction. In common with other endogenous hyperlipidemics, they manifest carbohydrate intolerance. 

It is likely that cases who have been described in the past as essential hyperlipemia on the basis of lipemic plasma and who exhibited tendon xanthomas belong in this group. Cases of essential hypercholesterolemia with and without plasma turbidity, whose plasma triglycerides exceed the levels expected from increased /3-lipoproteins, would qualify for membership. Such cases can be found in reports by Lever et al. (1954), Adlersberg (1955), Furman et al. (1961), Kuo and Basset (1963) and others. 

Recent findings from Fredrickson s laboratory (Fredrickson and Lees 1966) suggest that this group, too, is not homogenous. Its more common prototype is distinguished by the presence of large quantities of a 8-lipoprotein which floats at density 1.006 and which may represent an abnormal lipoprotein with increased affinity for both cholesterol and triglycerides. 

---