Endocrine system summary

In summary, it can be concluded that the acute toxicity of brominated flame retardants is relatively low. The long term effects on the balance of endocrine systems seems to present the greatest danger of these compounds. These endocrine effects need further consideration, since the majority of animals and man are exposed to these brominated flame retardants. The exposure range for humans via the food was calculated as 0.2-0.7 mg per day [96]. 

In summary, PCBs can affect a wide variety of endocrine systems by directly affecting the components of the endocrine system such as hormones, metabolic enzymes, carrier proteins, receptors, endocrine glands, and feedback regulation systems. Effects on these components can lead to alterations in neurodevelopment, reproduction, and in induction of endocrine-sensitive tumors. 

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