Endo molecular receptors

Bamberger CM, Schulte HM, Chrousos GP Molecular determinants of glucocorticoid receptor function and tissue sensitivity. Endo Rev... 

Fig. 3. Dendrimer architectural components as a function of molecular genealogy associated with CMDPs that contribute to endo- and exo-receptor properties...

Figure 2 Schematic representations of formation of discrete molecular complexes by an endo receptor and a exo substrate (a), by an exo receptor and two exo substrate acting as stoppers (b) and of a linear molecular network by an exo receptor and a connector (c).

Fig. 3. Model of the life cycle of prions. PrP is synthesized in the rough endoplas-matic reticulum (ER), and after passing through the secretory pathway including the Golgi and secretory vesicles, reaches the surface of a PrP infectable cell where it is anchored via a glycosylphosphatidyl inositol (GPI) moiety. Endocytosis of PrP and possibly PrP via clathrin coated vesicles could be mediated by the 37 kDa laminin receptor precursor (LRP). The uptake of the infectious agent could also be LRP independent. The conversion of the internalized PrP to PrP is thought to take place in the endo-somes, lysosomes, or endolysosomes. Molecular chaperones could be involved in this conversion process. PrP replication and aggregation can occur in neuronal cells of the brain but also in the cells constituting the lymphoreticular system. Alternatively, endocytosis and conversion of PrP into PrP could happen in caveolae-like domains (CLDs).

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