Encoding Methods for the OBOC Technique

2 Encoding Methods for the OBOC Technique. When screening is completed, one or several beads are identified that carry a compound of interest. Owing to the mix phenomenon, the chemical history (i.e., individual building blocks reacted with this particular bead) and the structure of the compound on the bead are not known. Consequently, the last step in the process is structure determination. 

Sequencing. In the initial experiments of the Lam group, peptide libraries were 

PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS 

The tags are generally cleaved from the resin using an orthogonal 

Rainbow Beads. Recently, color tagging of resin beads has also been developed. Polymer beads displaying chemical compounds or families of compounds were stained with oil-based organic dyes (red, blue, green, black, yellow) that were used as coding tags. The 

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