Encapsulation techniques effective barriers

Structural modifications and formulation are two additional approaches proposed for overcoming the enzymatic barrier (and references therein). Using recombinant or synthetic techniques, selective modifications to the protein or peptide sequence can be introduced effectively reducing proteolytic susceptibility, but these changes must not have significant impact on the pharmacological properties of the molecule (e.g., reduced potency or altered selectivity). Moreover, modifications to address a specific enzymatic action will not eliminate vulnerability to others. The formulation approach essentially involves encapsulation systems to protect the protein or peptide from reactions with enzymes, and selected examples include emulsions, liposomes, or enteric-coated capsules (and references therein). 

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