Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques

Department of Chemistry, University College of the Fraser Valley, Abbotsford, British Columbia, Canada 

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada 

Over the past 20 years, our laboratory has played a major role in the development of liposomal systems optimized for the delivery of conventional drugs, almost all of which are encapsulated by pH-gradient techniques. Our initial studies led to the development of several liposomal drug delivery systems in which uptake was driven by the citrate method of generating pH gradients (15,21-23,27,54—58). This was followed by the development of new 

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Encapsulation of Drugs Within Liposomes by pH-Gradient Techniques... 

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