Enantioselectivity of the Carboligation Reaction

Effects of high concentrations of benzaldehyde 4 on the enantioselectivity of the carboligation reaction have been described previously [4, 5]. Siegert et al. described the increase of R)-7 for a BED variant by increasing the concentration of benzaldehyde 4 from 1 to 10 mM, and Iding et al. were able to increase the enantioselectivity of wild-type BFD by keeping the concentration of benzaldehyde 4 at a low level. Surprisingly, acetaldehyde 6 showed no such effect. More recently, we 

Dtinnwald, L. Greiner, A. Liese, M. Muller, P. Siegert, J. 

Wilcocks, O. P. Ward, S. Collins, N. J. Dewdney, Y. Hong, E. Prosen, Appl. 

Sesenoglu, E. Eren, B. Hosrik, M. Pohl, E. Janzen, D. Kolter, R. Feldmann, P. Dtinkelmann, M. Muller, Adv. Synth. Catal. 2002, 344, 96-103. 

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