Enantioselectivity, carbene synthesis diazo compounds

These complexes can be isolated in some cases in others they are generated in situ from appropriate precursers, of which diazo compounds are among the most important. These compounds, including CH2N2 and others, react with metals or metal salts (copper, palladium, and rhodium are most commonly used) to give the carbene complexes that add CRR to double bonds.1063 Optically active complexes have been used for enantioselective cyclopropane synthesis.1064... 

Transition metal catalyzed carbene insertion into the Si—H bond provides a direct and efficient method for the synthesis of organosilicon compounds. When chiral spiro diimine ligand (/ )-24a was applied in Cu-catalyzed asymmetric insertion of a-diazo-a-arylacetates with silanes, the Si—H insertion products were obtained in high yields (85-97%) and excellent enantioselectivities (90-99% ee) (Scheme 51) [26a],... 

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