Enantioselective Hydrogenation of Enamines with Monodentate Phosphorus Ligands

Enantioselective Hydrogenation of Enamines with Monodentate Phosphorus Ligands 

NHAc [RhCI(COD)2]2/(S,S)-DIOP ( NHAo EtOH-CgHs (2 1), rt 

Chiral Amine Synthesis Methods, Developments and Applications. Edited by Thomas C. Nugent Copyright 2010 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-32509-2 

2 phenylenebis(endo 2,5 dialkyl 7 phosphabicyclo[2,2,l]heptane) [5], BDPAB (2,2 bis(diplienylpliospliinoaniino) 1,1 binaphthyl) [6], SpirOP ((1J ,5J ,6R) 1,6 bis (diphenylphosphinoxy)spiro[4.4] nonane) [7], TangPhos ((lS,l S,2fJ,2 fJ) 1,1 di tert butyl (2,2 ) diphospholane) [8], were reported to be efficient ligands in the rhodium catalyzed asymmetric hydrogenation of enamides. 

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