Enantioselective Capillary Gas Chromatography

Konig WA, Enantioselective capillary gas chromatography in the investigation of stereochemical correlations of terpenoids. Chirality 10 499—504, 1998. 

Mosandl A, Enantioselective capillary gas chromatography and stable isotope ratio mass spectrometry in the authenticity control of flavors and essential oils, Food Rev Int. 537—SSA, 1995. 

Konig WA, Krebber R, Evers P, Bruhn G, Stereochemical analysis of constituents of essential oils and flavor compounds by enantioselective capillary gas chromatography HRC 13 328—332, 1990. 

Maas B, Dietrich A, Mosandl A, Enantioselective capillary gas chromatography — Olfactometry in essential oil analysis, Naturwissenschafien 80 470 72,1993. 

Maas, B., A. Dietrich, and A. Mosandl, Enantioselective Capillary Gas Chromatography— Olfactometry in Essential Oil Analysis. Naturwissenschaften, 1993 80, 470-472. 

Konig, W. A, P, Evers, R, Krehber, S. Schulz, C. Fehr, and G. Ohloff, 1989. Determination of the absolute con guration of a-damascenone and a-ionone from black tea by enantioselective capillary gas chromatography. 45 7003-7006. 

WA Kdnig, U Sturm. Determination of optical purity by enantioselective capillary gas chromatography of panthenol and related compounds. J Chromatogr 328 357-361, 1985. 

E. Podehrad, M. Heil, S. Leih, B. Geier, T. Beck, A. Mosandl, A. C. Sewell and H. Bohles, Analytical approach in diagnosis of inherited metabolic diseases maple syrup urine disease (MSUD)-simultaneous analysis of metabolites in urine by enantioselective multidimensional capillary gas chromatography-mass specti ometiy (enantio-MDGC-MS) , 7. High Resolut. Chromatogr. 20 355-362(1997). 

Konig WA, Icheln D, RungeT, Pforr I, Krebs A, Cyclodextrins as chiral stationary phases in capillary gas chromatography, VII, Cyclodextrins with an inverse substitution pattern — Synthesis and enantioselectivity, /Resolut Chromatogr 13 702-707, 1990. 

Enantiomeric purity. In order to assess the efficiency of an enantioselective hydrolase-catalyzed reaction, it is imperative that one can accurately measure at least the conversion and the enantiomeric excesses of either the substrate or the product (see equations Equation 1, Equation 2, and Equation 3). Although optical rotation is sometimes used to assess enantiomeric excess, it is not recommended. Much better alternatives are various chromatographic methods. For volatile compounds, capillary gas chromatography on a chiral liquid phase is probably the most convenient method. Numerous commercial suppliers offer a large variety of columns with different chiral liquid phases. Hence it is often easy to find suitable conditions for enantioselective GC-separations that yield ee-values in excess of... 

A. Bemreuther, V. Lander, M. Huffer and P. Schreier. Enantioselective Analysis of Dec-2-en-5-oUde (MassoUactone) from Natural Sources by Multidimensional Capillary Gas Chromatography. Flav. Fragr. J., 5, 71-73 (1990). 

In this context, there has been a considerable development of enantioselective synthetic methodologies, which have now reached a high degree of diversity and complexity. Simultaneously, this trend has created an intensive demand for stereoselective separation techniques and analytical assays for precise determination of the enantiomeric purity of chiral compounds. The development of chiral stationary phases (CSPs) or chiral selectors for gas chromatography (GC), hquid chromatography (LC) and capillary electrophoresis (CE) rapidly opened a new dimension in the area of separation technologies. 

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