Enantiomerically pure lithium organics

210 is only 215 pm. A much more capable side-arm to fix the conformation at the meta-lated stereogenic center is the pyrrolidine-N,0 snbstituent, because it got two donor atoms to coordinate the lithium cation. The dimer [LiC2H2(Ph) C(Ph)-pyrrolidine-CH20Me ]2  

---

Before the emergence in the mid-1980s of the asymmetric deprotonation of cA-dimethyl cyclohexanone using enantiomerically pure lithium amide bases, few reports pertaining to the chemistry of these chiral reagents appeared. Although it is not the focus of this chapter, the optically active metal amide bases are still considered to be useful tools in organic synthesis. Readers are advised to consult the appropriate literature on the application of enantiomerically pure lithium amides in asymmetric synthesis.6... 

---