Enamine Radical Cation The Concept of SOMO Activation

3 Enamine Radical Cation The Concept of SOMO Activation 

Discussions hitherto have been on the energetic details of various modes of substrate activation leading to vital intermediates such as enamines and iminium ions. Once such reactive species are generated, the next important event in the reaction sequence is the new bond formation. The following section provides highlights of the bond-forming process, with particular emphasis on stereoselectivity issues. 

Boltzmann distribution of the competing transition states that are responsible for the final ratio between the enantiomers. If the free energy difference between pro-(R) and pro-(S) transition states are estimated at a given temperature, the %ee can be computed using the following equation  

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