Elliptinium acetate

C17H14N2O 51131-85-2) see Elliptinium acetate 3-hydroxyestra-l,3,5(10),6-tetraen-17-one (CijHtoOj 2208-72-0) see Estrone 17P-hydroxy-4-estrene... 

C,gH 6N20 10371-86-5) see Elliptinium acetate (liP)-ll-methoxyestra-4,9-diene-3,17-dione (C19H24O3 21391-55-9) see Moxestrol (17P)-3-methoxyestra-2,5(10)-dien-17-ol (C i)H2g02 1091-93-6) see Nandrolone 3-methoxyestra-l,3,5(10),16-tetraen-17-ol acetate (C21H26O3 6038-28-4) see Estriol (17P)-3-methoxyestra-l,3,5(10)-trien-17-ol (C19H26O2 1035-77-4) see Nandrolone... 

CisH -IN20 58447-24-8) sec Elliptinium acetate embonic acid... 

There is less information in the literature about binding of alkaloids to ribonucleic acid than there is for deoxyribonucleic acid but such binding does occur. However, since ribonucleic acid is single-stranded, the intercalation mechanism does not apply. Binding of the purine alkaloids caffeine and theophylline follows the reverse order from their binding to DNA — theopylline binds with 10,000 times the affinity of caffeine [345], Elliptinium acetate, best-known for its intercalation into DNA, is easily oxidized to an A-ring quinone amine that binds to the 2 -oxygen atom of ribose units in RNA. The first product then cyclizes to a spiro derivative [346]. 

Elliptinium, the 2-methyl derivative of 9-hydroxyellipticine (Figure 6.11) has been measured in plasma using an ODS-modified silica column and methanol-water (60-1-40) containing ammonium acetate (100 mmol L final pH 6.0) as eluent. Sample preparation was by ion-pair extraction into ethyl acetate containing sodium tetraphenylborate. The 2-propyl homologue was used as the internal standard. Detection was at a GCE (0.6 V V5 Ag/AgCl). The LoD was 250 pg (S/N = 2), equivalent to 25 pgL for a 200 pL sample. 

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