Elimination half life urinary excretion data

In a very early study, Shaffer et al. (1945) administered single oral doses of 5 and 10 g di(2-ethylhexyl) phthalate to two human subjects and reported that approximately 4.5% of the dose was excreted in the urine within 24 h. Schmid and Schlatter (1985) also administered di(2-ethylhexyl) phthalate orally to two human subjects, but at the much lower dose of 30 mg per person. These authors reported that 11-15% of the dose was excreted in the urine and a urinary elimination half-life of about 12 h can be estimated from the data. In the same study, the two volunteers also received 10 mg di(2-ethylhexyl) phthalate daily for four days, there being no evidence of accumulation, with 11 and 33 % of the dose recovered each day in the urine. In contrast, Rubin and Schififer (1976) reported data from two patients receiving platelet transfusions from bags containing di(2-ethylhexyl) phthalate, who excreted between 60 and 90% of the infused dose in the urine collected for 24 h after transfusion. 

Based on measured DNOC blood levels of a worker exposed to DNOC by a combination of inhalation and dermal routes (Pollard and Filbee 1951), an elimination rate constant of 0.002 hour and a half- life of 153.6 hours were determined (King and Harvey 1953b). A peak urinary quantity of 22 mg DNOC was found on the third day after the employee was admitted to the hospital and 5 weeks after his initial exposure (Pollard and Filbee 1951). About 89.9 mg of DNOC was eliminated via the urine over the 20 days after admission. The data suggest that humans have a relatively inefficient mechanism for eliminating DNOC and this may be due to slow detoxification and excretion or storage of DNOC in the body. 

---