Itraconazole Eletriptan

Drugs that may be affected by itraconazole include alfentanil, almotriptan, alprazolam, amphotericin B, aripiprazole, benzodiazepines, buspirone, busulfan, calcium blockers, carbamazepine, cilostazol, cisapride, corticosteroids, cyclosporine, digoxin, disopyramide, docetaxel, dofetilide, eletriptan, epierenone, ergot alkaloids, haloperidol, HMG-CoA reductase inhibitors, hydantoins (phenytoin), hypoglycemic agents, oral midazolam, phosphodiesterase type 5 inhibitors, pimozide, polyenes, protease inhibitors, quinidine, rifamycins, sirolimus, tacrolimus, tolterodine, triazolam, trimetrexate, vinca alkaloids, warfarin, and zolpidem. 

A4/3A5 Midazolam, buspirone, felodipine, lovastatin, eletriptan, sildenafil, simvastatin, triazolam Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin Rifampin, carbamazepine... 

Ketoconazole and fluconazole increase the AUC of eletriptan by about sixfold and twofold, respectively. Almotriptan is less affected, and ketoconazole only raises its AUC by about 60%. Itraconazole is predicted to interact in the same way as ketoconazole. 

Itraconazole, which is also a potent inhibitor of CYP3A4, has been predicted to interact in the same way as ketoconazole. " In addition, the US manufacturers recommend that eletriptan should not be given within 72 hours of itraconazole and ketoconazole. Fluconazole is a less potent inhibitor of CYP3A4 and therefore may be used with caution. Other triptans would be expected to have little or no interaction with the azoles as they are not predominantly metabolised by CYP3A4 (see Table 16.2 , (p.597)). 

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