Propanol electrostatic potential map

Electrostatic potential map for 2-propanol shows positively-charged regions (in blue) as likely acidic sites. 

Display and compare electrostatic potential maps for methanol, ethanol, 2-propanol and trifluoroethanol. Identify the acidic sites as those where the potential is most positive and, assuming that the more positive the potential the more acidic the site, rank the acidities of the compounds. Does increased alkyl substitution have a significant effect on acid strength What is the effect of replacing the methyl group in ethanol by a trifluoromethyl group Why Do you find a correlation between the most positive value of the potential and the experimental pKa ... 

Examine the electrostatic potential map of 1-propanol. Which atom is most negatively charged Most positively charged Use the maps to explain propanol s reactivity toward KH and HCI. 

Electrostatic potential map for 1-propanol, revealing the electron-rich (red) nature of the oxygen and the electron-poor (blue) nature of the attached proton. 

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See also in sourсe #XX -- [ ]

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