Electrospray ionization , APCI and

The specificity of the ions/decompositions must be considered. Both electrospray ionization and APCI are soft ionization techniques and the resulting mass... 

If a high -molecular-weight compound is being studied by LC-MS, the analyst has little choice in the ionization method to use, with atmospheric-pressure chemical ionization (APCI) being wholly inappropriate. However, when low -molecular-weight compounds are involved, both electrospray ionization and APCI are potentially of value. 

The logistical requirements of such an analysis are not stringent. Much of this work in the literature is transparent, since the details of such a sample manipulation are within the experimental section of a manuscript, and the work is not referenced or indexed as an application of TLC/MS. The references cited in this section are therefore more historical in nature, showing the development of the method through this logical first step in its development. Work of this sort continues with newer ionization methods, including electrospray ionization and APCI methods. As a caution, the flow of solvent that contains the sample extracted from a TLC separation should be passed through a fine particulate filter to remove the silica gel particles from the stream directed into the source of the mass spectrometer. 

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See also in sourсe #XX -- [ , , , , , , , , , , ]

See also in sourсe #XX -- [ , , , , , , , , , , ]

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