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Electron-rich arenes substrates, cyclizations

SCHEME 3.17 Cyclizations of substrates with electron-rich arenes. [Pg.56]

A synthesis of tylophorine 6.207 used an electron-rich arene as the carbon nucleophile (Scheme 6.92). The substrate was constructed by a sequence of two Suzuki couplings (Section 2.6), first an aryl-aryl coupling between iodide 6.201 and boronic acid 6.202, then an aryl-alkyne coupling, using an alkyne boronate 6.204 derived from proline. Platinum-catalysed cyclization generated the pyrrolidine 6.206, and the synthesis was completed by a one-pot deprotection-Pictet-Spengler reaction. [Pg.221]

See other pages where Electron-rich arenes substrates, cyclizations is mentioned: [Pg.225]    [Pg.41]    [Pg.44]    [Pg.196]    [Pg.472]    [Pg.155]    [Pg.1690]    [Pg.54]   
See also in sourсe #XX -- [ Pg.56 ]



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